Journal article

A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability

Michelle Luciano, Penelope A Lind, David L Duffy, Anne Castles, Margaret J Wright, Grant W Montgomery, Nicholas G Martin, Timothy C Bates

Biological Psychiatry | ELSEVIER SCIENCE INC | Published : 2007

Abstract

BACKGROUND: KIAA0319 (6p22.2) has recently been implicated as a susceptibility gene for dyslexia. We aimed to find further support for this gene by examining its association with reading and spelling ability in adolescent twins and their siblings unselected for dyslexia. METHODS: Ten single nucleotide polymorphisms (SNPs) in or near the KIAA0319 gene were typed in 440 families with up to five offspring who had been tested on reading and spelling tasks. Family-based association analyses were performed, including a univariate analysis of the principal component reading and spelling score derived from the Components of Reading Examination (CORE) test battery and a bivariate analysis of whole-wo..

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