Journal article
Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus
NJ Tobias, H Wolff, B Djahanschiri, F Grundmann, M Kronenwerth, YM Shi, S Simonyi, P Grün, D Shapiro-Ilan, SJ Pidot, TP Stinear, I Ebersberger, HB Bode
Nature Microbiology | NATURE PUBLISHING GROUP | Published : 2017
Abstract
Xenorhabdus and Photorhabdus species dedicate a large amount of resources to the production of specialized metabolites derived from non-ribosomal peptide synthetase (NRPS) or polyketide synthase (PKS). Both bacteria undergo symbiosis with nematodes, which is followed by an insect pathogenic phase. So far, the molecular basis of this tripartite relationship and the exact roles that individual metabolites and metabolic pathways play have not been well understood. To close this gap, we have significantly expanded the database for comparative genomics studies in these bacteria. Clustering the genes encoded in the individual genomes into hierarchical orthologous groups reveals a high-resolution p..
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Grants
Awarded by Alexander von Humboldt-Stiftung
Funding Acknowledgements
Research in the Bode Laboratory was supported by a European research starting grant under grant agreement no. 311477. H.B.B. acknowledges the Deutsche Forschungsgemeinschaft for funding of the Impact II qTof mass spectrometer (INST 161/810-1). N.J.T. and Y.M.S. are supported by a Postdoctoral Research Fellowship from the Alexander von Humboldt Foundation. S.J.P. is supported by an Australian National Health and Medical Research Council (NHMRC) project grant APP1105522. T.P.S. is supported by an Australian NHMRC Career Development Fellowship. I.E. acknowledges financial support by the Deutsche Forschungsgemeinschaft (DFG-FOR 2251, project grant EB 285/2-1).