Journal article

Cytotoxic and regulatory roles of mucosal-associated invariant T cells in type 1 diabetes

Ophelie Rouxel, Jennifer Da Silva, Lucie Beaudoin, Isabelle Nel, Celine Tard, Lucie Cagninacci, Badr Kiaf, Masaya Oshima, Marc Diedisheim, Marion Salou, Alexandra Corbett, Jamie Rossjohn, James McCluskey, Raphael Scharfmann, Manuela Battaglia, Michel Polak, Olivier Lantz, Jacques Beltrand, Agnes Lehuen

Nature Immunology | NATURE PUBLISHING GROUP | Published : 2017


Awarded by Agence Nationale de la Recherche

Awarded by Fondation pour la Recherche Medicale

Funding Acknowledgements

We thank all the patients and the medical staff of Necker hospital; A. Toubal for critical reading of the manuscript; F. Letourneur and A. Stabilini for technical help; the mouse, Cybio and HistIM facilities of the Cochin Institute; G, Eberl (Institut Pasteur, Paris) for the bacterial artificial chromosome expressing ROR gamma t-GFP; the US National Institutes of Health tetramer core facility; and H. Fohrer-Ting, R. Porcher and M. Laanani for help in statistical analyses. Supported by the Societe Francophone de Diabetologie (R.S.), the Foundation Bettencourt Schueller (R.S.), the Laboratoire d'Excellence REVIVE (R.S.), Fondation pour la Recherche Medicale (C.T., M.O. and M.D.), Type 1 Diabetes TrialNet (M.B.), Agence Nationale de la Recherche (NR-11-IDEX-0005-02 Laboratory of Excellence INFLAMEX to A.L.), Fondation pour la Recherche Medicale (DEQ20140329520 to A.L.), the INSERM crosscutting program on microbiota (A.L.), the European Foundation for the Study of Diabetes-Juvenile Diabetes Research Foundation-Lilly (A.L.), the Departement Hospitalo-Universitaire on Autoimmune and Hormonal Diseases (A.L.), the Ministry of Research (O. R.) and Aide aux Jeunes Diabetiques (I.N.).