Journal article

Evolutionary structure of Plasmodium falciparum major variant surface antigen genes in South America: Implications for epidemic transmission and surveillance

Virginie Rougeron, Kathryn E Tiedje, Donald S Chen, Thomas S Rask, Dionicia Gamboa, Amanda Maestre, Lise Musset, Eric Legrand, Oscar Noya, Erhan Yalcindag, Francois Renaud, Franck Prugnolle, Karen P Day

ECOLOGY AND EVOLUTION | WILEY | Published : 2017

Abstract

Strong founder effects resulting from human migration out of Africa have led to geographic variation in single nucleotide polymorphisms (SNPs) and microsatellites (MS) of the malaria parasite, Plasmodium falciparum. This is particularly striking in South America where two major founder populations of P. falciparum have been identified that are presumed to have arisen from the transatlantic slave trade. Given the importance of the major variant surface antigen of the blood stages of P. falciparum as both a virulence factor and target of immunity, we decided to investigate the population genetics of the genes encoding "Plasmodium falciparum Erythrocyte Membrane Protein 1" (Pf EMP1) among sever..

View full abstract

Grants

Awarded by National Institutes of Allergy and Infectious Diseases, National Institutes of Health


Funding Acknowledgements

This research was supported by the National Institutes of Allergy and Infectious Diseases, National Institutes of Health [grant number R01-AI084156].