Journal article
Colorectal cancer incidence in path_MLH1 carriers subjected to different follow-up protocols: A Prospective Lynch Syndrome Database report
T Seppälä, K Pylvänäinen, DG Evans, H Järvinen, L Renkonen-Sinisalo, I Bernstein, E Holinski-Feder, P Sala, A Lindblom, F Macrae, I Blanco, R Sijmons, J Jeffries, H Vasen, J Burn, S Nakken, E Hovig, EA Rødland, K Tharmaratnam, WH de Vos tot Nederveen Cappel Show all
Hereditary Cancer in Clinical Practice | BIOMED CENTRAL LTD | Published : 2017
Open access
Abstract
Background: We have previously reported a high incidence of colorectal cancer (CRC) in carriers of pathogenic MLH1 variants (path_MLH1) despite follow-up with colonoscopy including polypectomy. Methods: The cohort included Finnish carriers enrolled in 3-yearly colonoscopy (n = 505; 4625 observation years) and carriers from other countries enrolled in colonoscopy 2-yearly or more frequently (n = 439; 3299 observation years). We examined whether the longer interval between colonoscopies in Finland could explain the high incidence of CRC and whether disease expression correlated with differences in population CRC incidence. Results: Cumulative CRC incidences in carriers of path_MLH1 at 70-years..
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Funding Acknowledgements
The Finnish contribution: The Finnish Cancer Foundation, The Sigrid Juselius Foundation, Mary and Georg C. Ehrnrooth foundation, Jane and Aatos Erkko foundation and State Research Funding. The Spanish contribution: Spanish Ministry of Economy and Competitiveness, the Carlos III Health Institute, the Scientific Foundation Asociacion Espanola Contra el Cancer and the Government of Catalonia. The Welsh Contribution: Wales Gene Park. The study sponsors did not have a role in planning the study design; in the collection, analysis, or interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.