Journal article

XX Disorder of Sex Development is associated with an insertion on chromosome 9 and downregulation of RSPO1 in dogs (Canis lupus familiaris)

Vicki N Meyers-Wallen, Adam R Boyko, Charles G Danko, Jennifer K Grenier, Jason G Mezey, Jessica J Hayward, Laura M Shannon, Chuan Gao, Afrah Shafquat, Edward J Rice, Shashikant Pujar, Stefanie Eggers, Thomas Ohnesorg, Andrew H Sinclair

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2017

Grants

Awarded by National Institutes of Child Health and Human Development


Awarded by NSF (Cornell University CU-ADVANCE)


Awarded by National Institutes of Health General Medicine (G. Acland, Cornell Veterinary BioBank)


Awarded by American Kennel Club Canine Health Foundation


Awarded by National Institutes of Health


Awarded by NIH


Funding Acknowledgements

This work was supported in part by National Institutes of Child Health and Human Development R03HD077119 (M-W) and R01HD19393 (M-W) www.nichd.nih.gov, NSF HRD-0547373a (Cornell University CU-ADVANCE Accel grant, M-W) www.nsf.gov, National Institutes of Health General Medicine 5R24 GM082910 (G. Acland, Cornell Veterinary BioBank, M-W) www.nigms.nih.gov, the American Kennel Club Canine Health Foundation (#73552/A001, M-W, AB) www.akc.org, the Herndon Canine Disease Research fund (M-W), and the Collaborative Research Program, College of Veterinary Medicine (M-W), and the Baker Institute for Animal Health Pursuit of Excellence Fund (M-W), Cornell University, Ithaca, NY USA. Support for establishment of the canine XX DSD model was provided in part by National Institutes of Health Research Resources RR02512 and General Medicine GM32592 (PI: D.F. Patterson, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA). Collection of RNA-seq data at the Cornell University Biotechnology Resource Center (BRC) was enabled by an NIH grant (NIH 1S100D010693-01) for the Illumina HiSeq 2500. Andrew Sinclair was funded by the National Health and Medical Research Council of Australia www.nhmrc.gov.au. Chan Gao was not employed by PAREXEL International during the period in which he contributed to this study. PAREXEL International had no role in funding, study design, data collection and analysis, decision to publish, or preparation of the manuscript. Some funders provided support in the form of salaries for authors [M-W, AHS], but none had any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the 'author contributions' section. The contents of this publication are solely the responsibility of the authors and do not necessarily represent the views of the American Kennel Club Canine Health Foundation.