Journal article

Predictors of functional recovery in first-episode psychosis: A systematic review and meta-analysis of longitudinal studies

Olga Santesteban-Echarri, Mercedes Paino, Simon Rice, Cesar Gonzalez-Blanch, Patrick McGorry, John Gleeson, Mario Alvarez-Jimenez

CLINICAL PSYCHOLOGY REVIEW | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2017

Abstract

BACKGROUND: Three out of four first-episode psychosis (FEP) patients achieve clinical remission following treatment. Unfortunately, functional recovery lags behind symptomatic remission, and many individuals with FEP remain socially isolated with poor functional outcomes. AIMS: To systematically compile and analyse predictors of functional recovery in FEP. METHOD: Systematic review and meta-analysis of peer-reviewed, longitudinal studies reporting predictors of functioning, with a minimum 12-month follow-up and at least 80% of participants diagnosed with FEP. RESULTS: Out of 2205 citations, 274 articles were retrieved for detailed evaluation resulting in 50 eligible studies (N=6669). Sociode..

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Grants

Awarded by Spanish Ministry of Science and Innovation (MICINN)


Awarded by Spanish Ministry of Economy, Industry and Competitiveness (MINECO)


Awarded by National Health and Medical Research Council (NHMRC)


Funding Acknowledgements

The first author, O.S-E, was supported by a Research Fellowship from the Alicia Koplowitz Foundation (Spain) and an Endeavour Research Fellowship (Australia) for the completion of her fellowship and Ph.D. dissertation. The author M.P. was partially supported by the Spanish Ministry of Science and Innovation (MICINN) (PSI 2011-23818) and the Spanish Ministry of Economy, Industry and Competitiveness (MINECO) (PSI2016-79524-R). S.R. was supported by an Early Career Research Fellowship from the Australian Society for Mental Health Research (SMHR). Finally, M.A. was supported via a Career Development Fellowship (APP1082934) by the National Health and Medical Research Council (NHMRC). Funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.