Journal article
Does attentional dysfunction and thalamic atrophy predict decline in dementia with Lewy bodies?
R Watson, SJ Colloby, AM Blamire, KA Wesnes, J Wood, JT O'Brien
Parkinsonism and Related Disorders | ELSEVIER SCI LTD | Published : 2017
Abstract
Introduction To evaluate the clinical characteristics of DLB subjects who died within 1 year of assessment compared to those who survived and investigate their patterns of in vivo regional thalamic atrophy using structural MRI. Methods Seventy subjects (35 DLB, 35 aged controls) underwent 3 T T1-weighted MR scanning as well as clinical and cognitive assessments, including a computerised assessment of attention. All subjects were contacted after 12 months for reassessment. For both hemispheres, using FSL FIRST, the thalamus was automatically segmented followed by inter-subject vertex-wise analyses involving group comparisons and behavioural correlates. Results There was significant bilateral ..
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Awarded by National Institute for Health Research
Funding Acknowledgements
The study was funded by the Sir Jules Thorn Charitable Trust [grant ref: 05/JTA] and supported by the National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre in Ageing and Chronic Disease and Biomedical Research Unit in Lewy Body Dementia based at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University. Dr Watson is supported by the Yulgilbar Alzheimer's Research Program. Professor Wesnes owns Wesnes Cognition Ltd which provides internet based cognitive testing facilities to worldwide clinical trials. Professor O'Brien is supported by the Cambridge Biomedical Research Centre.