Journal article

The Ultra-High-Risk for psychosis groups: Evidence to maintain the status quo

MJ McHugh, PD McGorry, HP Yuen, IB Hickie, A Thompson, L de Haan, N Mossaheb, S Smesny, A Lin, C Markulev, M Schloegelhofer, SJ Wood, D Nieman, JA Hartmann, M Nordentoft, M Schafer, GP Amminger, A Yung, B Nelson

SCHIZOPHRENIA RESEARCH | ELSEVIER SCIENCE BV | Published : 2018

Abstract

Individuals are considered Ultra-High-Risk (UHR) for psychosis if they meet a set of standardised criteria including presumed genetic vulnerability (Trait), or a recent history of Attenuated Psychotic Symptoms (APS) or Brief Limited Intermittent Psychotic Symptoms (BLIPS). Recent calls to revise these criteria have arisen from evidence that Trait, APS and BLIPS groups may transition to psychosis at different rates. Concurrently, it has become clear that the UHR status confers clinical risk beyond transition to psychosis. Specifically, most UHR individuals will not develop psychosis, but will experience high rates of non-psychotic disorders, persistent APS and poor long-term functional outcom..

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