Journal article

Fibre-specific white matter changes in multiple sclerosis patients with optic neuritis

Sanuji Gajamange, David Raffelt, Thijs Dhollander, Elaine Lui, Anneke van der Walt, Trevor Kilpatrick, Joanne Fielding, Alan Connelly, Scott Kolbe



Long term irreversible disability in multiple sclerosis (MS) is thought to be primarily driven by axonal degeneration. Axonal degeneration leads to degenerative atrophy, therefore early markers of axonal degeneration are required to predict clinical disability and treatment efficacy. Given that additional pathologies such as inflammation, demyelination and oedema are also present in MS, it is essential to develop axonal markers that are not confounded by these processes. The present study investigated a novel method for measuring axonal degeneration in MS based on high angular resolution diffusion magnetic resonance imaging. Unlike standard methods, this novel method involved advanced acquis..

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Awarded by National Health and Medical Research Council

Awarded by Multiple Sclerosis Research Australia

Awarded by Victorian Life Sciences Computing Initiative (Resource Allocation Scheme)

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (APP1009757, APP1054147), Multiple Sclerosis Research Australia (Postgraduate Scholarship #14-088, SG), the Victorian Life Sciences Computing Initiative (Resource Allocation Scheme #1529, SK). We would like to thank Dr. Annie Shelton for insightful comments on the manuscript, and the Murdoch Children's Research Institute MRI Centre for significant assistance with data collection.