Journal article

Can molecular profiling enhance radiotherapy? Impact of personalized targeted gold nanoparticles on radiosensitivity and imaging of adenoid cystic carcinoma

Inbal Hazkani, Menachem Motiei, Oshra Betzer, Tamar Sadan, Dimitri Bragilovski, Leon Lubimov, Aviram Mizrachi, Tuvia Hadar, Mattan Levi, Irit Ben-Aharon, Izhack Haviv, Rachela Popovtzer, Aron Popovtzer

THERANOSTICS | IVYSPRING INT PUBL | Published : 2017

Abstract

Personalized molecular profiling has an established role in selection of treatment for metastatic disease; however, its role in improving radiosensitivity and functional imaging has not been evaluated. In the current study, we examined molecular profiling as a tool for designing personalized targeted gold nanoparticles (GNP) to serve as dual-modal tumor radiosensitizers and functional imaging enhancers. To this end, molecular profiling of a patient's salivary gland adenoid cystic carcinoma (ACC) was performed, and anaplastic lymphoma kinase (ALK) mutation was detected. The extracted tumor was subcutaneously injected into mice, which were then treated either with radiation, the specific ALK i..

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University of Melbourne Researchers