Journal article

Association of DNA Methylation-Based Biological Age With Health Risk Factors and Overall and Cause-Specific Mortality

Pierre-Antoine Dugue, Julie K Bassett, JiHoon E Joo, Laura Baglietto, Chol-Hee Jung, Ee Ming Wong, Giovanni Fiorito, Daniel Schmidt, Enes Makalic, Shuai Li, Margarita Moreno-Betancur, Daniel D Buchanan, Paolo Vineis, Dallas R English, John L Hopper, Gianluca Severi, Melissa C Southey, Graham G Giles, Roger L Milne



Measures of biological age based on blood DNA methylation, referred to as age acceleration (AA), have been developed. We examined whether AA was associated with health risk factors and overall and cause-specific mortality. At baseline (1990-1994), blood samples were drawn from 2,818 participants in the Melbourne Collaborative Cohort Study (Melbourne, Victoria, Australia). DNA methylation was determined using the Infinium HumanMethylation450 BeadChip array (Illumina Inc., San Diego, California). Mixed-effects models were used to examine the association of AA with health risk factors. Cox models were used to assess the association of AA with mortality. A total of 831 deaths were observed durin..

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Awarded by NHMRC

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by European Commission

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) of Australia (grants 1088405 and 1074383) and by the European Commission (H2020 grant 633666; L.B. was supported by a Marie Curie International Incoming Fellowship within the European Commission 7th Framework Programme. Cohort recruitment in the Melbourne Collaborative Cohort Study was funded by VicHealth and Cancer Council Victoria. The Melbourne Collaborative Cohort Study was further supported by NHMRC grants 209057 and 396414 and by infrastructure provided by Cancer Council Victoria. The nested case-control methylation studies were supported by NHMRC grants 1011618, 1026892, 1027505, 1050198, and 1043616.