Journal article

LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness

Jia-Min B Pang, Ramyar Molania, Ashwini Chand, Kevin Knower, Elena A Takano, David J Byrne, Thomas Mikeska, Ewan KA Millar, Cheok Soon Lee, Sandra A O'Toole, Colin Clyne, Kylie L Gorringe, Alexander Dobrovic, Stephen B Fox

ONCOTARGET | IMPACT JOURNALS LLC | Published : 2017

Abstract

The significance and regulation of liver receptor homologue 1 (LRH-1, NR5A2), a tumour-promoting transcription factor in breast cancer cell lines, is unknown in clinical breast cancers. This study aims to determine LRH-1/NR5A2 expression in breast cancers and relationship with DNA methylation and tumour characteristics. In The Cancer Genome Atlas breast cancer cohort NR5A2 expression was positively associated with intragenic CpG island methylation (1.4-fold expression for fully methylated versus not fully methylated, p=0.01) and inversely associated with promoter CpG island methylation (0.6-fold expression for fully methylated versus not fully methylated, p=0.036). LRH-1 immunohistochemistry..

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Grants

Awarded by National Breast Cancer Foundation


Funding Acknowledgements

National Breast Cancer Foundation (CG12-07 and CG10-04) and the Operational Infrastructure Support Program Funding of the Victorian State Government to the Olivia Newton-John Cancer Research Institute. KLG supported by the Victorian Cancer Agency.