Journal article
LRH-1 expression patterns in breast cancer tissues are associated with tumour aggressiveness
JMB Pang, R Molania, A Chand, K Knower, EA Takano, DJ Byrne, T Mikeska, EKA Millar, CS Lee, SA O'Toole, C Clyne, KL Gorringe, A Dobrovic, SB Fox
Oncotarget | IMPACT JOURNALS LLC | Published : 2017
Abstract
The significance and regulation of liver receptor homologue 1 (LRH-1, NR5A2), a tumour-promoting transcription factor in breast cancer cell lines, is unknown in clinical breast cancers. This study aims to determine LRH-1/NR5A2 expression in breast cancers and relationship with DNA methylation and tumour characteristics. In The Cancer Genome Atlas breast cancer cohort NR5A2 expression was positively associated with intragenic CpG island methylation (1.4-fold expression for fully methylated versus not fully methylated, p=0.01) and inversely associated with promoter CpG island methylation (0.6-fold expression for fully methylated versus not fully methylated, p=0.036). LRH-1 immunohistochemistry..
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Funding Acknowledgements
National Breast Cancer Foundation (CG12-07 and CG10-04) and the Operational Infrastructure Support Program Funding of the Victorian State Government to the Olivia Newton-John Cancer Research Institute. KLG supported by the Victorian Cancer Agency.