Role of TNF in lymphocyte-mediated cytotoxicity

Abstract

We now know that tumor necrosis factor (TNF) family ligands regulate development of lymphoid tissue and coordinate cellular differentiation to defend against intracellular pathogens. In particular, TNF provides essential signals for the formation of secondary lymphoid tissue structures and plays an important role in several physiological and pathological conditions that relate to its action in inflammation and leukocyte movement. The TNF-related family of membrane-anchored and secreted ligands also represents a major mechanism regulating cell death and cell survival. TNF was first described as an endotoxin-induced and macrophage secreted factor that caused haemorrhagic necrosis of tumor cell..