Journal article

Expression and function of the leucine zipper protein par-4 in apoptosis

SF Sells, SS Han, S Muthukkumar, N Maddiwar, R Johnstone, E Boghaert, D Gillis, GH Liu, P Nair, S Monnig, P Collini, MP Mattson, VP Sukhatme, SG Zimmer, DP Wood, JW McRoberts, Y Shi, VM Rangnekar

Molecular and Cellular Biology | AMER SOC MICROBIOLOGY | Published : 1997

Abstract

The prostate apoptosis response-4 (par-4) gene was identified by differential screening for genes that are upregulated when prostate cancer cells are induced to undergo apoptosis. The par-4 gene is induced by apoptotic signals but not by growth-arresting, necrotic, or growth-stimulatory signals. The deduced amino acid sequence of par-4 predicts a protein with a leucine zipper domain at its carboxy terminus. We have recently shown that the Par-4 protein binds, via its leucine zipper domain, to the zinc finger domain of Wilms' tumor protein WT1 (R. W. Johnstone et al., Mol. Cell. Biol. 16:6945-6956, 1996). In experiments aimed at determining the functional role of par-4 in apoptosis, an antise..

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