IFNγ signaling-Does it mean JAK-STAT?

Abstract

The molecular pathways involved in the cellular response to interferon (IFN)γ have been the focus of much research effort due to their importance in host defense against infection and disease, as well as its potential as a therapeutic agent. The discovery of the JAK-STAT signaling pathway greatly enhanced our understanding of the mechanism of IFNγ-mediated gene transcription. However, in recent years it has become apparent that other pathways, including MAP kinase, PI3-K, CaMKII and NF-κB, either co-operate with or act in parallel to JAK-STAT signaling to regulate the many facets of IFNγ biology in a gene- and cell type-specific manner. The complex interactions between JAK/STAT and alternate..