Journal article

Reducing Astrocytic Scarring after Traumatic Brain Injury with a Multifaceted Anti-Inflammatory Hydrogel System

Francesca L Maclean, Yi Wang, Rohan Walker, Malcolm K Horne, Richard J Williams, David R Nisbet

ACS BIOMATERIALS SCIENCE & ENGINEERING | AMER CHEMICAL SOC | Published : 2017

Abstract

Traumatic brain injury results in devastating long-term functional damage due to the growth inhibition of the inflammatory response, and in particular, the complex response of astrocytes. Sustained, nonsteroidal anti-inflammatory approaches that can attenuate this response are of interest to improve therapeutic outcomes, particularly when combined with a tissue engineering construct that recapitulates the physiological microenvironment to facilitate functional repair. Here, we present a multifaceted, therapeutic extracellular-matrix mimic consisting of a coassembled scaffold with a laminin-inspired self-assembling peptide hydrogel, Fmoc-DIKVAV, and the anti-inflammatory macromolecule, fucoid..

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Grants

Awarded by NHMRC


Funding Acknowledgements

This research was supported by funding from an NHMRC project grant (APP1020332). F.L.M. was supported by an Australian Postgraduate Award. M.K.H. was supported by an NHMRC Research Fellowship APP1020401. R.J.W. was supported by an Alfred Deakin Research Fellowship. D.R.N. was supported by an NHMRC Career Development Fellowship (APP1050684). Access to the facilities of the Australian National University Centre for Advanced Microscopy (CAM) with funding through the Australian Microscopy and Microanalysis Research Facility (AMMRF) is gratefully acknowledged, as is A/Prof Colin Jackson for the HPLC. The Florey Institute of Neuroscience and Mental Health receives infrastructure support from the Victorian State Government (Australia).