Journal article
Histological outcomes of anal high-grade cytopredictions
Jennifer Margaret Roberts, Fengyi Jin, Isobel Mary Poynten, Carmella Law, David James Templeton, Julia Kathleen Thurloe, Suzanne Marie Garland, Andrew Edwin Grulich, Annabelle Farnsworth, Richard John Hillman
CANCER CYTOPATHOLOGY | WILEY | Published : 2018
DOI: 10.1002/cncy.21936
Abstract
BACKGROUND: Longitudinal studies of histological outcomes after anal cytological screening in men who have sex with men (MSM) are rare. This study measured the positive predictive values (PPVs) of each level of baseline cytological abnormality in MSM in Sydney, Australia, over a 12-month period. METHODS: The Study of the Prevention of Anal Cancer is a 3-year prospective study of the natural history of anal human papillomavirus infection in MSM at least 35 years old. For each participant with a baseline cytological abnormality, the worst histology was recorded at the baseline high-resolution anoscopy and at 6 and 12 months. PPVs for a histological high-grade squamous intraepithelial lesion (H..
View full abstractGrants
Awarded by National Health and Medical Research Council
Awarded by Cancer Council New South Wales
Awarded by Andrew Edwin Grulich
Awarded by Isobel Mary Poynten
Awarded by David James Templeton
Funding Acknowledgements
The Study of the Prevention of Anal Cancer is funded by a National Health and Medical Research Council grant (568971) and a Cancer Council New South Wales grant (13-11). Cytological testing materials were provided by Hologic (Australia) Pty, Ltd. Andrew Edwin Grulich (grant 1081175), Isobel Mary Poynten (grant 1016307), and David James Templeton (grant 1013353) were supported by fellowships from the National Health and Medical Research Council. The Kirby Institute is affiliated with the Faculty of Medicine of the University of New South Wales and is funded by the Australian Government Department of Health and Ageing.