Journal article

Histological outcomes of anal high-grade cytopredictions

Jennifer Margaret Roberts, Fengyi Jin, Isobel Mary Poynten, Carmella Law, David James Templeton, Julia Kathleen Thurloe, Suzanne Marie Garland, Andrew Edwin Grulich, Annabelle Farnsworth, Richard John Hillman

CANCER CYTOPATHOLOGY | WILEY | Published : 2018

Abstract

BACKGROUND: Longitudinal studies of histological outcomes after anal cytological screening in men who have sex with men (MSM) are rare. This study measured the positive predictive values (PPVs) of each level of baseline cytological abnormality in MSM in Sydney, Australia, over a 12-month period. METHODS: The Study of the Prevention of Anal Cancer is a 3-year prospective study of the natural history of anal human papillomavirus infection in MSM at least 35 years old. For each participant with a baseline cytological abnormality, the worst histology was recorded at the baseline high-resolution anoscopy and at 6 and 12 months. PPVs for a histological high-grade squamous intraepithelial lesion (H..

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Grants

Awarded by National Health and Medical Research Council


Awarded by Cancer Council New South Wales


Awarded by Andrew Edwin Grulich


Awarded by Isobel Mary Poynten


Awarded by David James Templeton


Funding Acknowledgements

The Study of the Prevention of Anal Cancer is funded by a National Health and Medical Research Council grant (568971) and a Cancer Council New South Wales grant (13-11). Cytological testing materials were provided by Hologic (Australia) Pty, Ltd. Andrew Edwin Grulich (grant 1081175), Isobel Mary Poynten (grant 1016307), and David James Templeton (grant 1013353) were supported by fellowships from the National Health and Medical Research Council. The Kirby Institute is affiliated with the Faculty of Medicine of the University of New South Wales and is funded by the Australian Government Department of Health and Ageing.