Journal article

Genetic Predictors of Response to Serotonergic and Noradrenergic Antidepressants in Major Depressive Disorder: A Genome-Wide Analysis of Individual-Level Data and a Meta-Analysis

Katherine E Tansey, Michel Guipponi, Nader Perroud, Guido Bondolfi, Enrico Domenici, David Evans, Stephanie K Hall, Joanna Hauser, Neven Henigsberg, Xiaolan Hu, Borut Jerman, Wolfgang Maier, Ole Mors, Michael O'Donovan, Tim J Peters, Anna Placentino, Marcella Rietschel, Daniel Souery, Katherine J Aitchison, Ian Craig Show all

PLOS MEDICINE | PUBLIC LIBRARY SCIENCE | Published : 2012

Grants

Awarded by Innovative Medicine Initiative Joint Undertaking (IMI-JU)


Awarded by EC


Awarded by GlaxoSmithKline


Awarded by NIMH


Awarded by Medical Research Council


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Funding Acknowledgements

The research leading to these results has received support from the Innovative Medicine Initiative Joint Undertaking (IMI-JU) under grant agreement number 115008, of which resources are composed of European Union and the European Federation of Pharmaceutical Industries and Associations (EFPIA) in-kind contribution and financial contribution from the European Union's Seventh Framework Programme (FP7/2007-2013). EFPIA members Pfizer, GlaxoSmithKline, and Hoffmann-La Roche have contributed work and samples to the project presented here. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. GENDEP was funded by the European Commission Framework 6 grant, EC contract ref.: LSHB-CT-2003-503428. Lundbeck provided nortriptyline and escitalopram for the GENDEP study. GlaxoSmithKline and the UK National Institute for Health Research of the Department of Health contributed to the funding of the sample collection at the Institute of Psychiatry, London. GENDEP genotyping was funded by a joint grant from the UK Medical Research Council and GlaxoSmithKline (G0701420). GenPod was funded by the UK Medical Research Council and supported by the Mental Health Research Network. GODS study was partly supported by external funding provided by the Swiss branches of the following pharmaceutical companies: GlaxoSmithKline, Wyeth-Lederle, Bristol-Myers Squibb, and Sanofi Aventis. RU is supported by the Canada Research Chair program (http://www.chairs-chaires.gc.ca/). The authors thank the US National Institute of Mental Health (NIMH) for providing access to the STAR*D genetic dataset. STAR*D was funded by NIMH via contract (N01MH90003) to the University of Texas Southwestern Medical Center at Dallas (A. John Rush, principal investigator). STAR*D genotyping was supported by the NIMH grant to Steven P. Hamilton (grant number MH072802).r GB is a member of a national advisory board for Bristol-Myer Squibb and Pfizer and has received research funding from GlaxoSmithKline, Wyeth-Lederle, Bristol-Myers-Squibb, and Sanofi Aventis. ED and JRW are full-time employees of Roche. ED was a full time employee of GlaxoSmithKline when he undertook work on this study. SKH and XH are full-time employees of Pfizer. NH has participated in clinical trials sponsored by pharmaceutical companies including GlaxoSmithKline and Lundbeck and received honoraria for participating in expert panels from pharmaceutical companies including Lundbeck. MO'D's department received 2000 pound in lieu of an honorarium to MO'D from Lilly as a result of his participation in sponsored symposia in 2012. Those symposia were unrelated to the contents of this manuscript. MO'D holds grants from the Medical Research Council (UK), The Wellcome Trust, the National Institutes of Medicine (USA), and the European Union. None are relevant to the contents of this manuscript. DS is a member of a national advisory boards for Astra-Zeneca, Bristol-Myers Squibb, Eli Lilly, and Lundbeck. KJA is a member of a national advisory board for Johnson & Johnson, Lundbeck, Roche Diagnostics, and Bristol-Myers Squibb and Otsuka Pharmaceuticals Limited and has received consultancy fees and honoraria from Bristol-Myers Squibb, Lundbeck, Roche Molecular Systems, Roche Diagnostics, and Johnson & Johnson. KJA has received research and development consultancy fees and research support from Roche Diagnostics and Roche Molecular Systems.KJA has received research grants from Bristol-Myers Squibb and Otsuka Pharmaceuticals Limited; Johnson & Johnson Pharmaceutical Research and Development. PM and AF have previously received consultancy fees and honoraria for participating in expert panels from pharmaceutical companies including Lundbeck and GlaxoSmithKline, but have had no such income in the last 3 years. CML is on the Editorial Board of PLOS Medicine. TBS is a full time employee of Lundbeck. SK has received research funding from AstraZeneca, Bristol-Myers Squibb, and GlaxoSmithKline, and has served as consultant and/or speaker for AstraZeneca, Bioline, BMS-Otsuka, Eli Lilly, Janssen, Lundbeck, NeuroSearch, Pfizer, Roche, Servier, and Solvay Wyeth. All other authors have declared that no competing interests