Journal article
HPA axis genes, and their interaction with childhood maltreatment, are related to cortisol levels and stress-related phenotypes
L Gerritsen, Y Milaneschi, CH Vinkers, AM Van Hemert, L Van Velzen, L Schmaal, BWJH Penninx
Neuropsychopharmacology | NATURE PUBLISHING GROUP | Published : 2017
DOI: 10.1038/npp.2017.118
Abstract
Stress responses are controlled by the hypothalamus pituitary adrenal (HPA)-axis and maladaptive stress responses are associated with the onset and maintenance of stress-related disorders such as major depressive disorder (MDD). Genes that play a role in the HPA-axis regulation may likely contribute to the relation between relevant neurobiological substrates and stress-related disorders. Therefore, we performed gene-wide analyses for 30 a priori literature-based genes involved in HPA-axis regulation in 2014 subjects (34% male; mean age: 42.5) to study the relations with lifetime MDD diagnosis, cortisol awakening response, and dexamethasone suppression test (DST) levels (subsample N= 1472) an..
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Awarded by Johnson and Johnson
Funding Acknowledgements
The infrastructure for the NESDA study (www.nesda.nl) is funded through the Geestkracht program of The Netherlands Organization for Health Research and Development (Zon-Mw, grant number 10-000-1002) and is supported by participating universities and mental health-care organizations (VU University Medical Center, GGZ inGeest, Arkin, Leiden University Medical Center, GGZ Rivierduinen, University Medical Center Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Institute for Quality of Health Care (IQ Healthcare), Netherlands Institute for Health Services Research (NIVEL) and Netherlands Institute of Mental Health and Addiction (Trimbos)). NESDA's genetic data were supported by the National Institutes of Health (NIH, R01D0042157-01A, MH081802, Grand Opportunity grant 1RC2 MH089951), Center for Medical Systems Biology (CSMB, NWO Genomics) and the Biobanking and Biomolecular Resources Research Infrastructure (BBMRINL). CHV is supported by a Netherlands Organisation for Scientific Research VENI grant (451-13-001) and a Netherlands Brain Foundation Fellowship (F2013(1)-216). LG is supported by a Netherlands Organisation for Scientific Research VENI grant (916-14-016). BWJHP, LvV and LS are supported by a Netherlands Organisation for Scientific Research VICI grant (918-11-302), and has received research grant funding from Johnson & Johnson. LS gratefully acknowledges support from The Netherlands Brain Foundation (F2014(1)-24), the Neuroscience Campus Amsterdam (IPB-SE-15-PSYCH-Schmaal) and from the NIH Big Data to Knowledge (BD2K) award (U54 EB020403).