Journal article

DNA-Methylation and Body Composition in Preschool Children: Epigenome-Wide-Analysis in the European Childhood Obesity Project (CHOP)-Study

Peter Rzehak, Marcela Covic, Richard Saffery, Eva Reischl, Simone Wahl, Veit Grote, Martina Weber, Annick Xhonneux, Jean-Paul Langhendries, Natalia Ferre, Ricardo Closa-Monasterolo, Joaquin Escribano, Elvira Verduci, Enrica Riva, Piotr Socha, Dariusz Gruszfeld, Berthold Koletzko

Scientific Reports | NATURE PUBLISHING GROUP | Published : 2017

Grants

Awarded by Commission of the European Community, specific RTD Programme "Quality of Life and Management of Living Resources," within the 5th Framework Programme


Awarded by 6th Framework Programme


Awarded by European Union's Seventh Framework Programme Project EarlyNutrition


Awarded by Horizon research and innovation programme DYNAHEALTH


Awarded by European Research Council Advanced Grant META-GROWTH (ERC-AdG)


Awarded by German Ministry of Education and Research, Berlin


Funding Acknowledgements

The research reported herein was partially supported by the Commission of the European Community, specific RTD Programme "Quality of Life and Management of Living Resources," within the 5th Framework Programme (research grant nos. QLRT-2001-00389 and QLK1-CT-2002-30582); the 6th Framework Programme contract no. 007036 (FP6-007036); the European Union's Seventh Framework Programme Project EarlyNutrition under grant agreement no. 289346 (FP7-289346), the Horizon 2020 research and innovation programme DYNAHEALTH (no. 633595) and the European Research Council Advanced Grant META-GROWTH (ERC-2012-AdG - no. 322605). Additional support from the German Ministry of Education and Research, Berlin (Grant Nr. 01 GI 0825) and the University of Munich Innovative Research Priority Project MC-Health is gratefully acknowledged. This manuscript does not necessarily reflect the views of the Commission and in no way anticipates the future policy in this area. The funders of this study had no role in study design, data collection, data analysis, data interpretation, decision to publish, or preparation of the manuscript. RS is funded by a NHMRC Senior Research Fellowship and NHMRC: EU project grant and the MCRI by the Victorian Operational Infrastructure support scheme. The authors thank the participating families and all project partners for their enthusiastic support of the project work. Special thanks to Prof Dr Markus Ege, Dr von Hauner Children's Hospital, Ludwig-Maximilians Universitat Munchen (LMU), Munich and Dr Christoph Bernau from the Leibniz-Rechenzentrum (LRZ) in Garching/Munich for their great support with performing epigenetic analyses on the supercomputing facilities of the Leibniz-Rechenzentrum (LRZ).We also like to acknowledge the The European Childhood Obesity Trial Study Group for their continuous and salient support of the CHOP project: Philippe Goyens, Clotilde Carlier, Joana Hoyos, Pascale Poncelet, and Elena Dain (Universite Libre de Bruxelles-(ULB) -Brussels, Belgium); Jean-Noel Van Hees (CHC St Vincent-Francoise Martin, Annick Xhonneux, Jean-Paul Langhendries, and Jean-Noel Van Hees-Liege-Rocourt, Belgium); Ricardo Closa-Monasterolo, Joaquin Escribano, Veronica Luque, Georgina Mendez, Natalia Ferre, and Marta Zaragoza-Jordana (Universitat Rovira i Virgili, Institut d'Investigacio' Sanitaria Pere Virgili, Taragona, Spain); Marcello Giovannini, Enrica Riva, Carlo Agostoni, Silvia Scaglioni, Elvira Verduci, Fiammetta Vecchi, and Alice Re Dionigi (University of Milano, Milano, Italy); Jerzy Socha, Piotr Socha and Anna Stolarczyk (Children's Memorial Health Institute, Department of Gastroenterology, Hepatology and Immunology, Warsaw, Poland); Anna Dobrzanska and Dariusz Gruszfeld (Children's Memorial Health Institute, Neonatal Intensive Care Unit, Warsaw, Poland); Roman Janas (Children's Memorial Health Institute, Diagnostic Laboratory, Warsaw, Poland); Emmanuel Perrin (Danone Research Centre for Specialized Nutrition, Schiphol, the Netherlands); Rudiger von Kries (Division of Pediatric Epidemiology, Institute of Social Pediatrics and Adolescent Medicine, Ludwig Maximilians University of Munich, Munich, Germany); Helfried Groebe, Anna Reith, and Renate Hofmann (Klinikum Nurnberg Sued, Nurnberg, Germany); and Berthold Koletzko, Veit Grote, Martina Weber, Peter Rzehak, Sonia Schiess, Jeannette Beyer, Michaela Fritsch, Uschi Handel, Ingrid Pawellek, Sabine Verwied-Jorky, Iris Hannibal, Hans Demmelmair, Gudrun Haile, and Melissa Theurich (Division of Nutritional Medicine and Metabolism, Dr von Hauner Childrens Hospital, Ludwig-Maximilians Universitat Munchen (LMU),, Munich, Germany).