Rates and predictors of relapse following discontinuation of antipsychotic medication after a first episode of psychosis
Meghan Bowtell, Scott Eaton, Kristen Thien, Melissa Bardell-Williams, Linglee Downey, Aswin Ratheesh, Eoin Killackey, Patrick McGorry, Brian O'Donoghue
SCHIZOPHRENIA RESEARCH | ELSEVIER SCIENCE BV | Published : 2018
BACKGROUND: There is uncertainty about the required duration of long-term antipsychotic maintenance medication after a first episode of psychosis. Robust predictors of relapse after discontinuation are yet to be identified. The present study aimed to determine the proportion of young people who discontinue their antipsychotic medication after a first episode of psychosis, the proportion who experience relapse, and predictors of relapse. METHODS: A retrospective study of all individuals presenting to the Early Psychosis Prevention and Intervention Centre between 01/01/11 and 31/12/13 was conducted. A Cox regression analysis was conducted to identify predictors of relapse. RESULTS: A total of ..View full abstract
Professor PD McGorry is supported by a Research Fellowship from the National Health and Medical Research Council of Australia and is an NHMRC Senior Principal Research Fellow. Professor E Killackey is supported by a Career Development Fellowship from the National Health and Medical Research Council of Australia.