Conference Proceedings
Mitochondrial diseases and aging
DC Wallace, MT Lott, I Trounce, MD Brown, K Huoponen, N Krawiecki, JM Shoffner, F Palmieri (ed.), S Papa (ed.), C Saccone (ed.), MN Gadaleta (ed.)
THIRTY YEARS OF PROGRESS IN MITOCHONDRIAL BIOENERGETICS AND MOLECULAR BIOLOGY | ELSEVIER SCIENCE PUBL B V | Published : 1995
Abstract
Over the past seven years, a large number of mitochondrial DNA (mtDNA) base substitution and rearrangement mutations have been associated with a variety of degenerative diseases as well as aging. These disease processes preferentially affect the most metabolically active tissues, have a delayed onset, and progress. These clinical characteristics may be explained by the interaction between inherited and somatic mtDNA mutations.