Complete Surgical Excision Is Essential for the Management of Patients With Breast Implant-Associated Anaplastic Large-Cell Lymphoma.
Mark W Clemens, L Jeffrey Medeiros, Charles E Butler, Kelly K Hunt, Michelle A Fanale, Steven Horwitz, Dennis D Weisenburger, Jun Liu, Elizabeth A Morgan, Rashmi Kanagal-Shamanna, Vinita Parkash, Jing Ning, Aliyah R Sohani, Judith A Ferry, Neha Mehta-Shah, Ahmed Dogan, Hui Liu, Nora Thormann, Arianna Di Napoli, Stephen Lade Show all
Journal of Clinical Oncology | Published : 2016
PURPOSE: Breast implant-associated anaplastic large-cell lymphoma (BI-ALCL) is a rare type of T-cell lymphoma that arises around breast implants. The optimal management of this disease has not been established. The goal of this study is to evaluate the efficacy of different therapies used in patients with BI-ALCL to determine an optimal treatment approach. PATIENTS AND METHODS: In this study, we applied strict criteria to pathologic findings, assessed therapies used, and conducted a clinical follow-up of 87 patients with BI-ALCL, including 50 previously reported in the literature and 37 unreported. A Prentice, Williams, and Peterson model was used to assess the rate of events for each therap..View full abstract
Awarded by NCI NIH HHS