Journal article
Cost-effectiveness of artemisinin-naphthoquine versus artemether-lumefantrine for the treatment of uncomplicated malaria in Papua New Guinean children
BR Moore, WA Davis, PM Clarke, LJ Robinson, M Laman, TME Davis
Malaria Journal | BMC | Published : 2017
Abstract
Background: A recent randomized trial showed that artemisinin-naphthoquine (AN) was non-inferior to artemether-lumefantrine (AL) for falciparum malaria and superior for vivax malaria in young Papua New Guinean children. The aim of this study was to compare the cost-effectiveness of these two regimens. Methods: An incremental cost-effectiveness analysis was performed using data from 231 children with Plasmodium falciparum and/or Plasmodium vivax infections in an open-label, randomized, parallel-group trial. Recruited children were randomized 1:1 to receive once daily AN for 3 days with water or twice daily AL for 3 days given with fat. World Health Organisation (WHO) definitions were used to ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
We gratefully acknowledge the support of patients and their families, staff at the Mugil and Alexishafen Health Centres, and staff in the Vector Borne Disease Unit of the PNG Institute of Medical Research. The main trial was funded by a National Health and Medical Research Council of Australia Project Grant (#634343). BRM was supported by an NHMRC Early Career Fellowship (#1036951), ML an Australian Award PhD Scholarship, LJR by an NHMRC Early Career Fellowship (#1016443) and TMED a NHMRC Practitioner Fellowship (#572561).