Infectious Laryngotracheitis Virus Viral Chemokine-Binding Protein Glycoprotein G Alters Transcription of Key Inflammatory Mediators In Vitro and In Vivo
Mauricio JC Coppo, Joanne M Devlin, Alistair R Legione, Paola K Vaz, Sang-Won Lee, Jose A Quinteros, James R Gilkerson, Nino Ficorilli, Patrick C Reading, Amir H Noormohammadi, Carol A Hartley
JOURNAL OF VIROLOGY | AMER SOC MICROBIOLOGY | Published : 2018
Infectious laryngotracheitis virus (ILTV) is an alphaherpesvirus that infects chickens, causing upper respiratory tract disease and significant losses to poultry industries worldwide. Glycoprotein G (gG) is a broad-range viral chemokine-binding protein conserved among most alphaherpesviruses, including ILTV. A number of studies comparing the immunological parameters between infection with gG-expressing and gG-deficient ILTV strains have demonstrated that expression of gG is associated with increased virulence, modification of the amount and the composition of the inflammatory response, and modulation of the immune responses toward antibody production and away from cell-mediated immune respon..View full abstract
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This work was funded by an Australian Research Council (ARC) Discovery Project. J.M.D., S.-W.L., and J.A.Q. are funded by a Future Fellowship (ARC), a Development Early Career Research Award (ARC), and Becas Chile (CONICYT, Chilean Government), respectively.