Journal article
Evaluation of right heart function in a rat model using modified echocardiographic views
I Bernardo, J Wong, ME Wlodek, R Vlahos, P Soeding
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2017
Open access
Abstract
Echocardiography plays a major role in assessing cardiac function in animal models. We investigated use of a modified parasternal mid right-ventricular (MRV) and right ventricle (RV) outflow (RVOT) view, in assessing RV size and function, and the suitability of advanced 2D-strain analysis. 15 WKY rats were examined using transthoracic echocardiography. The left heart was assessed using standard short and long axis views. For the right ventricle a MRV and RVOT view were used to measure RV chamber and free wall area. 2D-strain analysis was applied to both ventricles using off-line analysis. RV chamber volume was determined by injection of 2% agarose gel, and RV free wall dissected and weighed...
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
[ "This work was supported by NHMRC Australia APP1084627.", "We thank Ms Chandra Lennie (GE Healthcare) and Mr Andrew Jefferies for technical support, Mr Adrian Cajili for designing the diagrams in Fig 1, and NHMRC Australia (grant 1084627) for funding." ]