A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort

S Pedrini; VB Gupta; E Hone; J Doecke; S O'Bryant; I James; AI Bush; CC Rowe; VL Villemagne; D Ames; CL Masters; RN Martins; G Savage; B Wilson; P Bourgeat; J Fripp; S Gibson; H Leroux; S McBride; O Salvado; M Fenech; M Francois; M Barnes; J Baker; K Barnham; S Bellingham; J Bomke; SB Pejoska; R Buckley; L Cheng; S Collins; I Cooke; E Cyarto; D Darby; V Dore; D El-Sheikh; N Faux; C Fowler; K Harrington; A Hill; M Horne; G Jones; A Kamer; N Killeen; H Korrel; F Lamb; N Lautenschlager; K Lennon; QX Li; YY Lim; A Louey; L Macaulay; L Mackintosh; P Maruff; A McIlroy; J Nigro; K Perez; K Pertile; C Restrepo; BR Cardoso; A Rembach; B Roberts; J Robertson; R Rumble; T Ryan; J Sach; B Silbert; C Thai; B Trounson; I Volitakis; M Vovos; L Ward; A Watt; R Williams; M Woodward; P Yates; FY Ugarte; P Zhang; S Bird; B Brown; S Burnham; P Chatterjee; K Cox; S Fernandez; B Fernando; S Gardener; S Laws; F Lim; L Lim; M Tegg; K Lucas; G Martins; T Porter; S Rainey-Smith; M Rodrigues; K Shen; H Sohrabi; K Taddei; T Taddei; S Tan

Journal article

A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort

S Pedrini, VB Gupta, E Hone, J Doecke, S O'Bryant, I James, AI Bush, CC Rowe, VL Villemagne, D Ames, CL Masters, RN Martins, G Savage, B Wilson, P Bourgeat, J Fripp, S Gibson, H Leroux, S McBride, O Salvado Show all

Scientific Reports | NATURE PORTFOLIO | Published : 2017

DOI: 10.1038/s41598-017-14020-9

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Abstract

Alzheimer's Disease (AD) is the most common form of dementia, characterised by extracellular amyloid deposition as plaques and intracellular neurofibrillary tangles of tau protein. As no current clinical test can diagnose individuals at risk of developing AD, the aim of this project is to evaluate a blood-based biomarker panel to identify individuals who carry this risk. We analysed the levels of 22 biomarkers in clinically classified healthy controls (HC), mild cognitive impairment (MCI) and Alzheimer's participants from the well characterised Australian Imaging, Biomarker and Lifestyle (AIBL) study of aging. High levels of IL-10 and IL-12/23p40 were significantly associated with amyloid de..

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University of Melbourne Researchers

Ashley Bush Author

Christopher Rowe Author

Victor Villemagne Author

David Ames Author

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

We thank all the participants who took part in this study and the clinicians who referred participants. The AIBL study (www.AIBL.csiro.au) is a collaboration between CSIRO, Edith Cowan University (ECU), National Ageing Research Institute (NARI), The Florey Institute of Neuroscience and Mental Health (FINMH) and Austin Health. It also received support from Hollywood Private Hospital, CogState Ltd., and Sir Charles Gairdner Hospital and funding support from Alzheimer's Australia (AA), CSIRO, the Science and Industry Endowment Fund, McCusker Alzheimer's Research Foundation, Brightfocus, USA and the WA Dept. of Health, as well as industry sources. The authors acknowledge the financial support of the Cooperative Research Centre (CRC) for Mental Health, which is an Australian Government Initiative. Pfizer International has provided financial support to assist with analysis of blood samples and to further the AIBL research program.