Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association
Onisha Patel, Michael DW Griffin, Santosh Panjikar, Weiwen Dai, Xiuquan Ma, Howard Chan, Celine Zheng, Ashleigh Kropp, James M Murphy, Roger J Daly, Isabelle S Lucet
Nature Communications | NATURE PUBLISHING GROUP | Published : 2017
Awarded by ARC Future Fellowships
Awarded by NHMRC Fellowships
Awarded by NHMRC IRIISS
Awarded by NHMRC
O.P. and M.D.W.G. were supported by ARC Future Fellowships (FT120100056 and FT140100544, respectively). J.M.M. and R.J.D. were supported by NHMRC Fellowships (1105754 and 1058540, respectively). Additional support was received from the Australian Cancer Research Foundation (to I.S.L., W.D., O.P., A. K. and C.Z.). I.S.L. acknowledges support from the Walter and Eliza Hall Institute of Medical Research. This work was also supported by funds from the Operational Infrastructure Support Program provided by the Victorian Government, Australia and NHMRC IRIISS 9000220, and in part by a Project Grant (1084621) from the NHMRC (to R.J.D.). Crystallization experiments were performed at CSIRO Collaborative Crystallization Centre (www.csiro.au/C3), Melbourne, Australia. We thank MX and SAXS beamline staff at the Australian Synchrotron where diffraction and scattering data were collected. We acknowledge the facilities, scientific and technical assistance of Monash Micro Imaging, Monash University, Victoria, Australia and Mandy Magias for technical assistance.