Journal article
Garcinia mangostana Linn displays antidepressant-like and pro-cognitive effects in a genetic animal model of depression: a bio-behavioral study in the Flinders Sensitive Line rat
I Oberholzer, M Möller, B Holland, OM Dean, M Berk, BH Harvey
Metabolic Brain Disease | SPRINGER/PLENUM PUBLISHERS | Published : 2018
Abstract
There is abundant evidence for both disorganized redox balance and cognitive deficits in major depressive disorder (MDD). Garcinia mangostana Linn (GM) has anti-oxidant activity. We studied the antidepressant-like and pro-cognitive effects of raw GM rind in Flinders Sensitive Line (FSL) rats, a genetic model of depression, following acute and chronic treatment compared to a reference antidepressant, imipramine (IMI). The chemical composition of the GM extract was analysed for levels of α- and γ-mangostin. The acute dose-dependent effects of GM (50, 150 and 200 mg/kg po), IMI (20 mg/kg po) and vehicle were determined in the forced swim test (FST) in FSL rats, versus Flinders Resistant Line (F..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The authors declare that this work has been funded by the South African National Research Foundation (BHH; grant number 77323). The grant-holder acknowledges that opinions, findings and conclusions or recommendations expressed in any publication generated by NRF supported research are those of the authors, and that the NRF accepts no liability whatsoever in this regard. This funder had no other role in the study. MB is supported by a NHMRC Senior Principal Research Fellowship 1,059,660.