Journal article
Relationship of human immunodeficiency virus viral load in cerebrospinal fluid and plasma in patients co-infected with cryptococcal meningitis
CC Chang, R Kangethe, S Omarjee, K Hiramen, B Gosnell, K Sojane, MYS Moosa, SR Lewin, MA French, T Ndung'u
Open Forum Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2017
DOI: 10.1093/ofid/ofx032
Abstract
We measured human immunodeficiency virus (HIV) ribonucleic acid (RNA) in paired cerebrospinal fluid (CSF) and plasma samples in a prospective study of 91 HIV-infected, antiretroviral therapy-naive patients with cryptococcal meningitis. Cerebrospinal fluid HIV RNA was lower than in plasma (median 4.7 vs 5.2 log10 copies/mL, P < .0001) and positively correlated with plasma HIV RNA, peripheral CD4+ T-cell percentage, and CSF CXCL10. Plasma/CSF ratio of HIV RNA ranged widely from 0.2 to 265.5 with a median of 2.6. Cerebrospinal fluid quantitative cryptococcal culture positively correlated with CSF CCL2 and CCL3. CSF-plasma viral discordance was not associated with cryptococcal-associated immune ..
View full abstractRelated Projects (2)
Grants
Awarded by Howard Hughes Medical Institute
Funding Acknowledgements
This work was funded by the REACH Initiative ([Research and Education in HIV/AIDS for Resource Poor Countries] to M.A.F.) and Pfizer Neuroscience (Grant NS052.10; to C.C.C.). C.C.C. is supported by the Australian National Health and Medical Research Council (NHMRC) Early Career Fellowship APP1092160. M.A.F. was supported by NHMRC Grant 510448. S.R.L. is an NHMRC practitioner fellow APP1042654. T.N. was supported in part by an International Early Career Scientist grant from the Howard Hughes Medical Institute and by the South African Department of Science and Technology/National Research Foundation Research Chairs Initiative. Open Access publication of this article has been made possible through support from the Victor Daitz Information Gateway, an initiative of the Victor Daitz Foundation and the University of KwaZulu-Natal.