Long-term health outcomes of adults with McCune-Albright syndrome

Abstract

Context: McCune-Albright syndrome (MAS) is associated with numerous health problems. Comprehensive long-term health problems of adults with MAS are less well defined in the literature. Objective: Our objective is to report comprehensive health outcomes of adults with MAS (>18 years). Design: Retrospective case note review of 16 adults with MAS managed by one clinician. Results expressed as median (range). Results: The study included 16 adults (seven males) with MAS. Median current age is 29 years (20, 46). Twelve of 16 had craniofacial fibrous dysplasia with five of 12 (42%) with progressive facial asymmetry. Growth hormone excess was observed in six of 16 (38%) and T3-toxicosis in five of 1..