Vitamin D status is associated with executive function a decade later: Data from the Women's Healthy Ageing Project

AM Goodwill; S Campbell; S Simpson; M Bisignano; C Chiang; L Dennerstein; C Szoeke

Journal article

Vitamin D status is associated with executive function a decade later: Data from the Women's Healthy Ageing Project

AM Goodwill, S Campbell, S Simpson, M Bisignano, C Chiang, L Dennerstein, C Szoeke

Maturitas | ELSEVIER IRELAND LTD | Published : 2018

DOI: 10.1016/j.maturitas.2017.10.005

Abstract

Objectives Vitamin D deficiency has been associated with cognitive decline and dementia in older adults. However, there is a paucity of studies assessing whether this association manifests from midlife. Given the long prodromal stage of dementia, we investigated the association between midlife vitamin D and cognition 10 years later. Study design 252 participants (aged 55–67 years) from the Women's Healthy Ageing Project had baseline (2002) vitamin D and neuropsychological measures assessed. Of these, 170 (aged 65–77 years) had follow-up neuropsychological testing (2012). Outcome measures Serum 25-hydroxyvitamin D (25[OH]D) was measured using an automated chemiluminescence system. The neurops..

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University of Melbourne Researchers

Steve Simpson-Yap Author

Cherie Chiang Author

Lorraine Dennerstein Author

Cassandra Szoeke Author

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Grants

Awarded by Alzheimer's Association

Funding Acknowledgements

Funding for the Healthy Ageing Program (HAP) has been provided by the National Health and Medical Research Council (NHMRC Grants 547600, 1032350 & 1062133), Ramaciotti Foundation, Australian Healthy Ageing Organisation, the Brain Foundation, the Alzheimer's Association (NIA320312), Australian Menopausal Society, Bayer Healthcare, Shepherd Foundation, Scobie and Claire Mackinnon Foundation, Collier Trust Fund, J.O. & J.R. Wicking Trust, Mason Foundation and Alzheimer's Australia. Inaugural funding was provided by VicHealth and the NHMRC. The Principal Investigator of HAP (CSz) is supported by the National Health and Medical Research Council.