Journal article
Causes of blood methylomic variation for middle-aged women measured by the HumanMethylation450 array
S Li, EM Wong, TL Nguyen, JHE Joo, J Stone, GS Dite, GG Giles, R Saffery, MC Southey, JL Hopper
Epigenetics | TAYLOR & FRANCIS INC | Published : 2017
Abstract
To address the limitations in current classic twin/family research on the genetic and/or environmental causes of human methylomic variation, we measured blood DNA methylation for 479 women (mean age 56 years) including 66 monozygotic (MZ), 66 dizygotic (DZ) twin pairs and 215 sisters of twins, and 11 random technical duplicates using the HumanMethylation450 array. For each methylation site, we estimated the correlation for pairs of duplicates, MZ twins, DZ twins, and siblings, fitted variance component models by assuming the variation is explained by genetic factors, by shared and individual environmental factors, and by independent measurement error, and assessed the best fitting model. We ..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
[ "The AMDTSS was facilitated through the Australian Twin Registry, a national research resource in part supported by a Centre for Research Excellence Grant from the National Health and Medical Research Council (NHMRC) APP 1079102. The AMDTSS was supported by NHMRC (grant numbers 1050561 and 1079102), Cancer Australia and National Breast Cancer Foundation (grant number 509307).", "SL is supported by the Australian Government Research Training Program Scholarship from the University of Melbourne. TLN is supported by a NHMRC Post-Graduate Scholarship and the Richard Lovell Travelling Scholarship from the University of Melbourne. MCS is a NHMRC Senior Research Fellow of NHMRC. JLH is a NHMRC Senior Principal Research Fellow." ]