Journal article
Very high carriage of gametocytes in asymptomatic low-density Plasmodium falciparum and P. vivax infections in western Thailand
W Nguitragool, I Mueller, C Kumpitak, T Saeseu, S Bantuchai, R Yorsaeng, S Yimsamran, W Maneeboonyang, P Sa-Angchai, W Chaimungkun, P Rukmanee, S Puangsa-Art, N Thanyavanich, C Koepfli, I Felger, J Sattabongkot, P Singhasivanon
Parasites Vectors | BMC | Published : 2017
Abstract
BACKGROUND: Low-density asymptomatic infections of Plasmodium spp. are common in low endemicity areas worldwide, but outside Africa, their contribution to malaria transmission is poorly understood. Community-based studies with highly sensitive molecular diagnostics are needed to quantify the asymptomatic reservoir of Plasmodium falciparum and P. vivax infections in Thai communities.METHODS: A cross-sectional survey of 4309 participants was conducted in three endemic areas in Kanchanaburi and Ratchaburi provinces of Thailand in 2012. The presence of P. falciparum and P. vivax parasites was determined using 18S rRNA qPCR. Gametocytes were also detected by pfs25 / pvs25 qRT-PCRs.RESULTS: A tota..
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Awarded by Wellcome Trust
Funding Acknowledgements
This study was supported by the TransEPI consortium funded by the Bill & Melinda Gates Foundation (www.gatesfoundation.org), a NHMRC Project Grant (#1021455, www.nhmrc.gov.au), Swiss National Science Foundation grant (310030_159580, www.snf.ch), and National Institutes of Health (NIH) grants (D43TW006571 and U19AI089672). WN was supported by a Wellcome Trust Intermediate Fellowship in Public Health and Tropical Medicine (101,073/Z/13Z). IM was supported by a NHMRC Senior Research Fellowship (#1043345). This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS.