Journal article

Risk factors and pregnancy outcomes associated with placental malaria in a prospective cohort of Papua New Guinean women

Elvin Lufele, Alexandra Umbers, Jaume Ordi, Maria Ome-Kaius, Regina Wangnapi, Holger Unger, Nandao Tarongka, Peter Siba, Ivo Mueller, Leanne Robinson, Stephen Rogerson



BACKGROUND: Plasmodium falciparum in pregnancy results in substantial poor health outcomes for both mother and child, particularly in young, primigravid mothers who are at greatest risk of placental malaria (PM) infection. Complications of PM include maternal anaemia, low birth weight and preterm delivery, which contribute to maternal and infant morbidity and mortality in coastal Papua New Guinea (PNG). METHODS: Placental biopsies were examined from 1451 pregnant women who were enrolled in a malaria prevention study at 14-26 weeks gestation. Clinical and demographic information were collected at first antenatal clinic visits and women were followed until delivery. Placental biopsies were col..

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Awarded by Malaria in Pregnancy Consortium through Bill & Melinda Gates Foundation

Awarded by Pregvax Consortium, through European Union's Seventh Framework Programme

Awarded by Pfizer Inc.

Awarded by NHMRC

Funding Acknowledgements

This study was funded by the Malaria in Pregnancy Consortium, through a grant from the Bill & Melinda Gates Foundation (46099); the Pregvax Consortium, through a grant from the European Union's Seventh Framework Programme FP7-2007-HEALTH (PREGVAX 201588) and the Spanish Government (EUROSALUD 2008 Programme); and Pfizer Inc., through an investigator-initiated research grant (WS394663). LR was supported by an NHMRC Early Career Fellowship (# 1016443). The funders had no role in study design, data collection and analyses; decision to publish or preparation of the manuscript.