Cancer exosomes in cerebrospinal fluid

Abstract

Cancer cells secrete extracellular vesicles (EVs), including exosomes, which contain a varied cargo of tumour-specific genetic material such as DNA, mRNA and miRNA. EVs possess the ability to manipulate various functional and pathological characteristics of the donor and recipient cells, in addition to facilitating modifications of the tumour microenvironment, firstly during disease progression and also in response to clinical treatment. 'Liquid biopsy' platforms, such as blood based tests for monitoring cancer progression and response to therapeutics, have been part of oncologic care for decades. However, further development of biofluid-based methodologies is required as an important step n..