Preparing for genomic medicine: a real world demonstration of health system change
Clara L Gaff, Ingrid M Winship, Susan M Forrest, David P Hansen, Julian Clark, Paul M Waring, Mike South, Andrew H Sinclair
NPJ GENOMIC MEDICINE | SPRINGER NATURE, CO-PUBL CTR EXCELLENCE GENOMIC MED RES | Published : 2017
Organisations and governments seeking to implement genomics into clinical practice face numerous challenges across multiple, diverse aspects of the health care system. It is not sufficient to tackle any one aspect in isolation: to create a system that supports genomic medicine, they must be addressed simultaneously. The growing body of global knowledge can guide decision-making, but each jurisdiction or organisation needs a model for genomic (or personalised) medicine that is tailored to its unique context, its priorities and the funds available. Poor decisions could greatly reduce the benefits that could potentially arise from genomic medicine. Demonstration projects enable models to be tes..View full abstract
We wish to thank all collaborators in the Melbourne Genomics Health Alliance demonstration project (Appendix 1). This work would not have been possible without the leadership of each founding member organisation-Dr Gareth Goodier, Prof Doug Hilton, Prof Kathryn North, Sue Forrest, Prof Christine Kilpatrick, Prof Stephen Smith and Prof Lynne Cobiac-and the chair of the steering committee, Prof James Angus. We thank Dr Melissa Martyn for critical input into development of the programme logic, Dr Helen Jordan for comments on the programme logic, Dr Natalie Thorne and Tim Bakker for contribution to the development of the information management platform and the contribution of unpublished data by members of the hCRC flagship (Alex Boussioutas, Finlay Macrae, Alison Trainer, Ingrid Winship, Michael Bogwitz, Ivan Macciocca, Sebastian Lunke, Ella Wilkins and Emma Creed) and the hereditary neuropathy flagship (Monique Ryan, Maie Walsh, Paul James, Tim Day, Lynette Kiers, Eppie Yiu, Zornitza Stark, Alicia Oshlack, Adrienne Sexton, Belinda Chong, and Gemma Brett). Dr James Dromey co-developed the proposal for funding, and Leeanne Cavanough provided assistance with manuscript preparation. We also thank Prof Angus Clarke for his helpful comments on this article. The study was funded by the founding organisations of the Melbourne Genomics Health Alliance (Royal Melbourne Hospital, Royal Children's Hospital, University of Melbourne, Walter and Eliza Hall Institute, Murdoch Childrens Research Institute, Australian Genome Research Facility and CSIRO) and the State Government of Victoria (Department of Health and Human Services). The involvement of AGRF was supported by sponsorship from Bioplatforms Australia and the NCRIS program.