Journal article

Rattling the border wall: Pathophysiological implications of functional and proteomic venom variation between Mexican and US subspecies of the desert rattlesnake Crotalus scutulatus

James Dobson, Daryl C Yang, Bianca op den Brouw, Chip Cochran, Huynh Tam, Sanjaya Kurrupu, Elda E Sanchez, Daniel J Massey, Kate Baumann, Timothy NW Jackson, Amanda Nouwens, Peter Josh, Edgar Neri-Castro, Alejandro Alagon, Wayne C Hodgson, Bryan G Fry

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY | ELSEVIER SCIENCE INC | Published : 2018

Abstract

While some US populations of the Mohave rattlesnake (Crotalus scutulatus scutulatus) are infamous for being potently neurotoxic, the Mexican subspecies C. s. salvini (Huamantlan rattlesnake) has been largely unstudied beyond crude lethality testing upon mice. In this study we show that at least some populations of this snake are as potently neurotoxic as its northern cousin. Testing of the Mexican antivenom Antivipmyn showed a complete lack of neutralisation for the neurotoxic effects of C. s. salvini venom, while the neurotoxic effects of the US subspecies C. s. scutulatus were time-delayed but ultimately not eliminated. These results document unrecognised potent neurological effects of a M..

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