Systematic review, and meta-analysis of steroid-sparing effect, of biologic agents in randomized, placebo-controlled phase 3 trials for systemic lupus erythematosus
Shereen Oon, Molla Huq, Timothy Godfrey, Mandana Nikpour
SEMINARS IN ARTHRITIS AND RHEUMATISM | W B SAUNDERS CO-ELSEVIER INC | Published : 2018
OBJECTIVES: To systematically review, and conduct a meta-analysis of steroid-sparing effect in, phase 3 randomized, placebo-controlled trials of biologic therapies for systemic lupus erythematosus (SLE). METHODS: Studies were identified by searching Medline (via Pubmed), EMBASE, CINAHL and SCOPUS databases, the Cochrane library, and clinicaltrials.gov. Adult human studies published in English in the last ten years (until 18/04/2017) were included. A random-effects meta-analysis comparing a common corticosteroid-reduction endpoint in the trials of rituximab, belimumab, tabalumab and epratuzumab in SLE, was conducted. RESULTS: Twenty-eight studies were identified; nine were conducted in SLE, f..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC)
Mandana Nikpour is supported by a National Health and Medical Research Council (NHMRC) Career Development Fellowship (APP1126370). Shereen Oon is supported by a postdoctoral fellowship from Arthritis Australia/Arthritis Victoria.