Journal article
Human CD141 dendritic cell and CD1c dendritic cell undergo concordant early genetic programming after activation in humanized mice in vivo
Y Minoda, I Virshup, IL Rojas, O Haigh, Y Wong, JJ Miles, CA Wells, KJ Radford
Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2017
Abstract
Human immune cell subsets develop in immunodeficient mice following reconstitution with human CD34+ hematopoietic stem cells. These "humanized" mice are useful models to study human immunology and human-tropic infections, autoimmunity, and cancer. However, some human immune cell subsets are unable to fully develop or acquire full functional capacity due to a lack of cross-reactivity of many growth factors and cytokines between species. Conventional dendritic cells (cDCs) in mice are categorized into cDC1, which mediate T helper (Th)1 and CD8+ T cell responses, and cDC2, which mediate Th2 and Th17 responses. The likely human equivalents are CD141+ DC and CD1c+ DC subsets for mouse cDC1 and cD..
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Awarded by Center for Outcomes Research and Evaluation, Yale School of Medicine
Funding Acknowledgements
The project was funded by the National Health and Medical Research Council of Australia project grants 604306 and 1078987 and Career Development Fellowships 1008986 (KR) and 1131732 (JM), Australian Research Council Future Fellowship (CW), and by the Mater Foundation, Brisbane Australia. The Translational Research Institute is supported by a grant from the Australian Government.