Journal article
Reproductive factors as risk modifiers of breast cancer in BRCA mutation carriers and high-risk non-carriers
B Park, JL Hopper, AK Win, JG Dowty, HK Sung, C Ahn, SW Kim, MH Lee, J Lee, JW Lee, E Kang, JH Yu, KS Kim, BI Moon, W Han, DY Noh, SK Park, BS Kwak, BW Park, BH Son Show all
Oncotarget | IMPACT JOURNALS LLC | Published : 2017
Abstract
This study was conducted to identify the role of reproductive factors as environmental modifiers for breast cancer (BC) risk in clinic-based, East-Asian BRCA1 and BRCA2 mutation carriers and non-carriers with high-risk criteria of BRCA mutations (family history (FH) of BC, early-onset BC (aged =40 years)). A total of 581 women who were BRCA carriers (222 BRCA1 and 359 BRCA2), 1,083 non-carriers with FH, and 886 non-carriers with early-onset BC were enrolled and interviewed to examine the reproductive factors, from 2007 to 2014. The hazard ratio (HR) and its 95% confidence interval (CI) in the weighted Cox regression model were used to calculate the BC risk based on the reproductive factors. ..
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Awarded by Ministry of Science, ICT and Future Planning
Funding Acknowledgements
This study was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (#1020350 and #1420190), a Grant-in-Aid for Cancer Research and Control from the National Cancer Center of Korea (#1710171), Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2016R1C1B1013621), and a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI16C1127).