Journal article

Cannabis use in early psychosis is associated with reduced glutamate levels in the prefrontal cortex

Silvia Rigucci, Lijing Xin, Paul Klauser, Philipp S Baumann, Luis Alameda, Martine Cleusix, Raoul Jenni, Carina Ferrari, Maurizio Pompili, Rolf Gruetter, Kim Q Do, Philippe Conus

PSYCHOPHARMACOLOGY | SPRINGER | Published : 2018

Abstract

RATIONALE: Recent studies have shown that cannabis may disrupt glutamate (Glu) signaling depressing Glu tone in frequent users. Current evidence have also consistently reported lower Glu-levels in various brain regions, particularly in the medial prefrontal cortex (mPFC) of chronic schizophrenia patients, while findings in early psychosis (EP) are not conclusive. Since cannabis may alter Glu synaptic plasticity and its use is a known risk factor for psychosis, studies focusing on Glu signaling in EP with or without a concomitant cannabis-usage seem crucial. OBJECTIVE: We investigate the effect of cannabis use on prefrontal Glu-levels in EP users vs. both EP non-users and healthy controls (HC..

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Grants

Awarded by Swiss National Science Foundation


Awarded by National Center of Competence in Research (NCCR) "SYNAPSY" - Swiss National Science Foundation


Funding Acknowledgements

This work was supported by the Swiss National Science Foundation (320030_122419 to P.C. and K.Q.D), National Center of Competence in Research (NCCR) "SYNAPSY (P.K and L.A - The Synaptic Bases of Mental Diseases" financed by the Swiss National Science Foundation (no 51AU40_125759). P.S.B. was supported by the Leenaards and Jeantet foundation. Magnetic resonance spectroscopy war performed in the Centre d'Imagerie BioMedicale (CIBM) of the UNIL, UNIGE, HUG, CHUV, EPFL.