Journal article

Alteration of Cardiac ACE2/Mas Expression and Cardiac Remodelling in Rats with Aortic Constriction

Yanling Zhang, Bing Li, Bingxiang Wang, Jingjun Zhang, Junyan Wu, Trefor Morgan

CHINESE JOURNAL OF PHYSIOLOGY | CHINESE PHYSIOLOGICAL SOC | Published : 2014

Abstract

The recent discovery of the new components of the renin-angiotensin system (RAS) suggests the importance of the maintenance of cardiovascular structure and functions. To assess the role of the angiotensin-converting enzyme 2 (ACE2)-Mas receptor axis in the regulation of cardiac structure and function, the present work investigated the expression of ACE2 and Mas receptor in the heart in the cardiac remodeling that occurs in aortic constricted rats. Partial abdominal aortic ligation was carried out in Sprague-Dawley rats. Angiotensin AT1 receptor blockade and ACE inhibition were achieved by losartan and enalapril treatment, respectively. Results showed that aortic constriction increased left v..

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