Developing drugs targeting transition metal homeostasis
Claire M Weekley, Chuan He
CURRENT OPINION IN CHEMICAL BIOLOGY | ELSEVIER SCI LTD | Published : 2017
Metal dyshomeostasis is involved in the pathogenesis and progression of diseases including cancer and neurodegenerative diseases. Metal chelators and ionophores are well known modulators of transition metal homeostasis, and a number of these molecules are in clinical trials. Metal-binding compounds are not the only drugs capable of targeting transition metal homeostasis. This review presents recent highlights in the development of chelators and ionophores for the treatment of cancer and neurodegenerative disease. Moreover, we discuss the development of small molecules that alter copper and iron homeostasis by inhibiting metal transport proteins. Finally, we consider the emergence of metal re..View full abstract
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Awarded by National Institutes of Health
Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
The authors acknowledge colleagues whose work was not cited due to space limitations. CMW is supported by a National Health and Medical Research Council (NHMRC) CJ Martin Fellowship. CH is an investigator of the Howard Hughes Medical Institute (HHMI) and is supported by National Institutes of Health GM071440.