Journal article

CLUSTERIN LEVELS INCREASE DURING NEURONAL DEVELOPMENT

MK OBRYAN, SS CHEEMA, PF BARTLETT, BF MURPHY, MJ PEARSE

JOURNAL OF NEUROBIOLOGY | JOHN WILEY & SONS INC | Published : 1993

Abstract

The expression of clusterin has been shown to be elevated in several models of experimentally induced programmed cell death and in association with a number of neurodegenerative conditions. In order to test whether this protein is expressed in neurons during development, the expression of clusterin was examined in the developing nervous system, using immunohistochemistry and mRNA analysis. Clusterin expression was observed in the earliest neurons of the cortical plate on embryonic day (E) 12. Thereafter, the intensity of clusterin staining continued to increase in an age-dependent manner, with the greatest intensity of staining being found in the postnatal mature brain. Virtually all neurons..

View full abstract

University of Melbourne Researchers