Journal article

DIFFERENTIAL EXPRESSION OF CLUSTERIN IN INDUCIBLE MODELS OF APOPTOSIS

MJ PEARSE, M OBRYAN, N FISICARO, L ROGERS, B MURPHY, AJ DAPICE

INTERNATIONAL IMMUNOLOGY | OXFORD UNIV PRESS UNITED KINGDOM | Published : 1992

Abstract

Apoptosis (programmed cell death) and necrosis can be readily distinguished morphologically and biochemically. The most striking biochemical change observed in apoptotic cells is the cleavage of the genomic DNA into discrete nucleosome sized fragments, producing a laddering pattern when the DNA is examined electrophoretically. It has recently been shown that RNA and protein products of the testosterone-repressed prostate message-2 gene are induced, coordinate with the onset of cell death. This gene has been isolated from a variety of species and tissues, it is highly conserved, and collectively referred to as clusterin. We have examined a number of inducible leucocyte models of apoptosis, in..

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University of Melbourne Researchers