Journal article
Peripheral transcription of NRG-ErbB pathway genes are upregulated in treatment-resistant schizophrenia
MS Mostaid, TT Lee, G Chana, S Sundram, CS Weickert, C Pantelis, I Everall, C Bousman
Frontiers in Psychiatry | FRONTIERS MEDIA SA | Published : 2017
Abstract
Investigation of peripheral gene expression patterns of transcripts within the NRG-ErbB signaling pathway, other than neuregulin-1 (NRG1), among patients with schizophrenia and more specifically treatment-resistant schizophrenia (TRS) is limited. The present study built on our previous work demonstrating elevated levels of NRG1 EGFα, EGFβ, and type I(Ig2) containing transcripts in TRS by investigating 11 NRG-ErbB signaling pathway mRNA transcripts (NRG2, ErbB1, ErbB2, ErbB3, ErbB4, PIK3CD, PIK3R3, AKT1, mTOR, P70S6K, eIF4EBP1) in whole blood of TRS patients (N = 71) and healthy controls (N = 57). We also examined the effect of clozapine exposure on transcript levels using cultured peripheral..
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Grants
Awarded by Sylvia and Charles Viertel Charitable Foundation
Funding Acknowledgements
The authors acknowledge the financial support of the CRC for Mental Health. The Cooperative Research Centre (CRC) programme is an Australian Government Initiative. The authors also wish to acknowledge the CRC Scientific Advisory Committee, in addition to the contributions of study participants, clinicians at recruitment services, staff at the Murdoch Children's Research Institute, staff at the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Aging, and research staff at the Melbourne Neuropsychiatry Centre, including coordinators, C. Phassouliotis, A. Merritt, and research assistants, A. Burnside, H. Cross, S. Gale, and S. Tahtalian. Participants for this study were sourced, in part, through the Australian Schizophrenia Research Bank (ASRB), which is supported by the National Health and Medical Research Council of Australia (Enabling Grant N. 386500), the Pratt Foundation, Ramsay Health Care, the Viertel Charitable Foundation, and the Schizophrenia Research Institute. The authors thank the Chief Investigators and ASRB Manager, V. Carr, U. Schall, R. Scott, A. Jablensky, B. Mowry, P. Michie, S. Catts, F. Henskens, C. Pantelis, C. Loughland. The authors acknowledge the help of Jason Bridge for ASRB database queries. MM was supported by a Cooperative Research Centre for Mental Health Top-up Scholarship. SS was supported by One-in-Five Association Incorporated. CSW is supported by Schizophrenia Research Institute (utilizing infrastructure funding from the NSW Ministry of Health and the Macquarie Group Foundation), the University of New South Wales, and Neuroscience Research Australia. CSW is a recipient of a National Health and Medical Research Council (Australia) Principal Research Fellowship (PRF) (#1117079). CP was supported by an NHMRC Senior Principal Research Fellowship (628386 and 1105825), and a Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award. CB was supported by a NHMRC Career Development Fellowship (1127700) and Brain and Behavior Research Foundation (NARSAD) Young Investigator Award (20526). None of the funding sources played any role in the study design; collection, analysis, or interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.