Journal article

Moderators and mediators of effects of unloading shoes on knee pain in people with knee osteoarthritis: an exploratory analysis of the SHARK randomised controlled trial

KL Paterson, J Kasza, KL Bennell, TV Wrigley, BR Metcalf, PK Campbell, DJ Hunter, RS Hinman

OSTEOARTHRITIS AND CARTILAGE | ELSEVIER SCI LTD | Published : 2018

Abstract

OBJECTIVE: To investigate moderators and biomechanical mediators of effects of unloading shoes on knee pain in people with knee osteoarthritis (OA). METHODS: Exploratory analysis from 164 participants in a clinical trial comparing unloading (ASICS GEL-Melbourne OA) to conventional walking shoes. The primary outcome was 6-month change in knee pain (11-point numerical rating scale (NRS)). Moderators included baseline peak knee adduction moment (KAM), radiographic severity (Kellgren & Lawrence (KL) scale), body mass, foot posture, neuropathic pain and diffuse knee pain. Mediators included change in peak KAM and KAM impulse. RESULTS: Radiographic severity was the only moderator to interact with ..

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Grants

Awarded by Australian National Health and Medical Research Council


Awarded by Australian Research Council Future Fellowship


Awarded by National Health & Medical Research Council Fellowship


Awarded by National Health & Medical Research Council Practitioner Fellowship


Funding Acknowledgements

The trial was funded by the Australian National Health and Medical Research Council (Project #1044396). RSH is supported by an Australian Research Council Future Fellowship (FT130100175). KLB is supported by a National Health & Medical Research Council Fellowship (#1058440). DJH is supported by a National Health & Medical Research Council Practitioner Fellowship (#1079777).