Journal article
Impaired placental autophagy in placental malaria
KG Dimasuay, L Gong, F Rosario, E McBryde, T Spelman, J Glazier, SJ Rogerson, JG Beeson, T Jansson, RJ Devenish, P Boeuf
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2017
Abstract
Background: Placental malaria is a major cause of low birthweight, principally due to impaired fetal growth. Intervillositis, a local inflammatory response to placental malaria, is central to the pathogenesis of poor fetal growth as it impairs transplacental amino acid transport. Given the link between inflammation and autophagy, we investigated whether placental malaria-associated intervillositis increased placental autophagy as a potential mechanism in impaired fetal growth. Methods: We examined placental biopsies collected after delivery from uninfected women (n = 17) and from women with Plasmodium falciparum infection with (n = 14) and without (n = 7) intervillositis. Western blotting an..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne [Henry and Rachael Ackman Travelling Scholarship to KGD]; the National Institutes of Health [RHD68370 to TJ] and the Australian National Health and Medical Research Council [program grant 1092789 to JGB and SJR]. The Burnet Institute is supported by the Australian National Health and Medical Research Council Independent Research Institutes Infrastructure Support Scheme, and a Victoria State Government Operational Infrastructure Support grant. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.